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PREMARIN® (conjugated estrogens) Contraindications


PREMARIN therapy is contraindicated in individuals with any of the following conditions:

  • Undiagnosed abnormal genital bleeding
  • Known, suspected, or history of breast cancer except in appropriately selected patients being treated for metastatic disease
  • Known or suspected estrogen-dependent neoplasia
  • Active DVT, PE, or a history of these conditions
  • Active arterial thromboembolic disease (for example stroke and MI), or a history of these conditions
  • Known anaphylactic reaction or angioedema with Premarin
  • Known liver impairment or disease
  • Known protein C, protein S or antithrombin deficiency, or other known thrombophilic disorders.
  • Known or suspected pregnancy

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